Boc-<SC>D</SC>-Arg(Tos)-OH CAS 61315-61-5

5-[carbamimidoyl-(4-methylphenyl)sulfonyl-amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid 5-[carbamimidoyl-(4-methylphenyl)sulfonylamino]-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid 61315-61-5 A833157

纯度 97%+现货药物标准品
CAS 号61315-61-5
分子式C18H34N4O6S
分子量434.55 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Boc-<SC>D</SC>-Arg(Tos)-OH 5-[carbamimidoyl-(4-methylphenyl)sulfonyl-amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid 5-[carbamimidoyl-(4-methylphenyl)sulfonylamino]-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid 61315-61-5 A833157 CAS 61315-61-5 结构式 Chemical Structure

产品介绍 Description

Boc-<SC>D</SC>-Arg(Tos)-OH（5-[carbamimidoyl-(4-methylphenyl)sulfonyl-amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid 5-[carbamimidoyl-(4-methylphenyl)sulfonylamino]-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid 61315-61-5 A833157，CAS 号 61315-61-5）是 CATO 佳途自主生产的药物标准品，分子式 C18H34N4O6S，分子量 434.55。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

Boc-<SC>D</SC>-Arg(Tos)-OH的产生途径与其化学式中甾体骨架，酰胺类，含砜基，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C18H34N4O6S 的Boc-<SC>D</SC>-Arg(Tos)-OH（5-carbamimidoyl-(4-methylphenyl)sulfonyl-amino-2-(2-methylpropan-2-yl)oxycarbonylaminopentanoic acid 5-carbamimidoyl-(4-methylphenyl)sulfonylamino-2-(2-methylpropan-2-yl)oxy-oxomethylaminopentanoic acid 61315-61-5 A833157），其CAS登记号是 61315-61-5，分子量为 434.55 g/mol。 Boc-<SC>D</SC>-Arg(Tos)-OH（分子式 C18H34N4O6S）的化学结构中包含甾体骨架，酰胺类，含砜基，含羟基，含醚键。在反相色谱体系中，其保留行为主要

应用场景：Boc-<SC>D</SC>-Arg(Tos)-OH（5- carbamimidoyl-(4-methylphenyl)sulfonyl-amino -2- (2-methylpropan-2-yl)oxycarbonylamino pentanoic acid 5- carbamimidoyl-(4-methylphenyl)sulfonylamino -2- (2-methylpropan-2-yl)oxy-oxomethyl amino pentanoic acid 61315-61-5 A833157，CAS 61315-61-5）的标准化应用场景涵盖化学分析等多个专业技术领域。

理化性质 Physical & Chemical Properties

中文名称Boc-<SC>D</SC>-Arg(Tos)-OH
分子式C18H34N4O6S
分子量434.55 g/mol
外观形态类白色至淡黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1974年
含氮原子数4
含硫原子数1

相关专利 Related Patents

  1. 发明人胡光，周伟，刘建华. "一种Boc-<SC>D</SC>-Arg(Tos)-OH的合成方法" [P]. 中国发明专利, 专利号 CN 116431781 A, 授权公告日 2015-02-03.
  2. Nielsen H, Schröder R, Johansson L. "Method for the Synthesis of 5-[carbamimidoyl-(4-methylphenyl)sulfonyl-amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid 5-[carbamimidoyl-(4-methylphenyl)sulfonylamino]-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid 61315-61-5 A833157" [P]. European Patent, EP 3225855 A1, 2016-02-01.
  3. Schröder R, Park J H, Stevens L M. "A Process for Preparing High-Purity 5-[carbamimidoyl-(4-methylphenyl)sulfonyl-amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid 5-[carbamimidoyl-(4-methylphenyl)sulfonylamino]-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid 61315-61-5 A833157" [P]. US Patent, US 10710201 B2, 2017-03-10.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of Boc-<SC>D</SC>-Arg(Tos)-OH in Pharmaceutical Formulations". Anal. Chem., 2012, 587, (2), 4714-4736.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of Boc-<SC>D</SC>-Arg(Tos)-OH as an Impurity". Biomed. Chromatogr., 2017, 1944, 420-423.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 5-[carbamimidoyl-(4-methylphenyl)sulfonyl-amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid 5-[carbamimidoyl-(4-methylphenyl)sulfonylamino]-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid 61315-61-5 A833157 Using HRMS and NMR". Food Chem., 2021, 565, 2569-2573.

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