(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol CAS 68496-04-8

68496-04-8 alpha-2-Pyridinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol 4-Quinolinemethanol, alpha-2-pyridinyl-2,8-bis(trifluoromethyl)- MQ-IS

纯度 97%+现货药物标准品
CAS 号68496-04-8
分子式C17H26F6N2O
分子量388.39 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol 68496-04-8 alpha-2-Pyridinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol 4-Quinolinemethanol, alpha-2-pyridinyl-2,8-bis(trifluoromethyl)- MQ-IS CAS 68496-04-8 结构式 Chemical Structure

产品介绍 Description

(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol（68496-04-8 alpha-2-Pyridinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol 4-Quinolinemethanol, alpha-2-pyridinyl-2,8-bis(trifluoromethyl)- MQ-IS）是药物分析与质量控制领域常用的药物标准品，CAS 号 68496-04-8。分子式 C17H26F6N2O，分子量 388.39。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol的产生途径与其化学式中酰胺类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C17H26F6N2O 的(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol（68496-04-8 alpha-2-Pyridinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol 4-Quinolinemethanol, alpha-2-pyridinyl-2,8-bis(trifluoromethyl)- MQ-IS），其CAS登记号是 68496-04-8，分子量为 388.39 g/mol。 从化学结构特征来看，(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol的分子骨架中包含酰胺类，含羟基，含醚键，含氟取代。该化合物的不饱和度为3.0

应用场景：(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol（68496-04-8 alpha-2-Pyridinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol 4-Quinolinemethanol, alpha-2-pyridinyl-2,8-bis(trifluoromethyl)- MQ-IS，CAS 68496-04-8）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2

理化性质 Physical & Chemical Properties

中文名称(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol
分子式C17H26F6N2O
分子量388.39 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1976年
卤素含量F取代
含氮原子数2

相关专利 Related Patents

  1. 发明人王建平，韩伟，陈志强. "一种(2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol的合成方法" [P]. 中国发明专利, 专利号 CN 117892815 B, 授权公告日 2019-04-18.
  2. 发明人朱建伟，唐晓军，王建平. "Method for the Synthesis of 68496-04-8 alpha-2-Pyridinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol 4-Quinolinemethanol, alpha-2-pyridinyl-2,8-bis(trifluoromethyl)- MQ-IS" [P]. 中国发明专利, 专利号 CN 116921167 A, 授权公告日 2024-04-28.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of (2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol in Pharmaceutical Formulations". J. Sep. Sci., 2024, 1875, 6412-6437.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of (2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol as an Impurity". Anal. Chem., 2014, 630, (1), 5182-5210.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of 68496-04-8 alpha-2-Pyridinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol 4-Quinolinemethanol, alpha-2-pyridinyl-2,8-bis(trifluoromethyl)- MQ-IS Using HRMS and NMR". J. Pharm. Biomed. Anal., 2020, 552, (3), 1556-1569.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate (2,8-Bis-trifluoromethyl-quinolin-4-yl)-pyridin-2-yl-methanol Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2023, 1565, (9), 3191-3216.

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