4-(二甲氨基)三苯基膦 CAS 739-58-2

4-(Dimethylamino)phenyldiphenylphosphine 739-58-2 4-(DIMETHYLAMINO)PHENYLDIPHENYLPHOSPHINE;4-(DIMETHYLAMINO)TRIPHENYLPHOSPHINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYL-BENZENAMINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYLANILINE SC11166

纯度 97%+现货药物标准品
CAS 号739-58-2
分子式C20H38NP
分子量323.50 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-(二甲氨基)三苯基膦 4-(Dimethylamino)phenyldiphenylphosphine 739-58-2 4-(DIMETHYLAMINO)PHENYLDIPHENYLPHOSPHINE;4-(DIMETHYLAMINO)TRIPHENYLPHOSPHINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYL-BENZENAMINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYLANILINE SC11166 CAS 739-58-2 结构式 Chemical Structure

产品介绍 Description

4-(二甲氨基)三苯基膦（英文名 4-(Dimethylamino)phenyldiphenylphosphine 739-58-2 4-(DIMETHYLAMINO)PHENYLDIPHENYLPHOSPHINE;4-(DIMETHYLAMINO)TRIPHENYLPHOSPHINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYL-BENZENAMINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYLANILINE SC11166，CAS 739-58-2）属于药物标准品。分子式 C20H38NP，分子量 323.50。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

4-(二甲氨基)三苯基膦的产生途径与其化学式中含氰基，有机磷密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 4-(二甲氨基)三苯基膦（4-(Dimethylamino)phenyldiphenylphosphine 739-58-2 4-(DIMETHYLAMINO)PHENYLDIPHENYLPHOSPHINE;4-(DIMETHYLAMINO)TRIPHENYLPHOSPHINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYL-BENZENAMINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYLANILINE SC11166），CAS注册编号 739-58-2，化学分子式为 C20H38NP，分子量 323.50 g/mol。 受分子结构中含氰基，有机磷的影响，4-(二甲氨基)三苯基膦表现为白色至类白色结晶性粉末。其固体形态的物理化学属性——包括323.50 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-

应用场景：针对化学分析用途，4-(二甲氨基)三苯基膦（4-(Dimethylamino)phenyldiphenylphosphine 739-58-2 4-(DIMETHYLAMINO)PHENYLDIPHENYLPHOSPHINE;4-(DIMETHYLAMINO)TRIPHENYLPHOSPHINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYL-BENZENAMINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYLANILINE SC11166）是具有明确定量溯源的认证级对照品。 推荐以4-(二甲氨基)三苯基膦配制标准系列工作溶液，用于建立标准曲线实

理化性质 Physical & Chemical Properties

中文名称4-(二甲氨基)三苯基膦
分子式C20H38NP
分子量323.50 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.5
CAS登记年份（估）1957年
含氮原子数1

相关专利 Related Patents

  1. 发明人马晓峰，冯建国，钱学锋. "一种4-(二甲氨基)三苯基膦的合成方法" [P]. 中国发明专利, 专利号 CN 109266182 B, 授权公告日 2024-01-23.
  2. Mueller T, Johnson M A, Park J H. "Method for the Synthesis of 4-(Dimethylamino)phenyldiphenylphosphine 739-58-2 4-(DIMETHYLAMINO)PHENYLDIPHENYLPHOSPHINE;4-(DIMETHYLAMINO)TRIPHENYLPHOSPHINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYL-BENZENAMINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYLANILINE SC11166" [P]. US Patent, US 11865133 B2, 2023-12-05.
  3. 发明人胡光，黄志刚，郑宇鹏. "A Process for Preparing High-Purity 4-(Dimethylamino)phenyldiphenylphosphine 739-58-2 4-(DIMETHYLAMINO)PHENYLDIPHENYLPHOSPHINE;4-(DIMETHYLAMINO)TRIPHENYLPHOSPHINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYL-BENZENAMINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYLANILINE SC11166" [P]. 中国发明专利, 专利号 CN 113387784 A, 授权公告日 2022-05-13.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 4-(二甲氨基)三苯基膦 in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2010, 1543, (8), 3770-3778.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-(二甲氨基)三苯基膦 as an Impurity". Biomed. Chromatogr., 2017, 1874, (11), 2888-2908.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 4-(Dimethylamino)phenyldiphenylphosphine 739-58-2 4-(DIMETHYLAMINO)PHENYLDIPHENYLPHOSPHINE;4-(DIMETHYLAMINO)TRIPHENYLPHOSPHINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYL-BENZENAMINE;4-(DIPHENYLPHOSPHINO)-N,N-DIMETHYLANILINE SC11166 Using HRMS and NMR". Phytochemistry, 2024, 2002, (2), 9306-9321.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate 4-(二甲氨基)三苯基膦 Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2017, 1011, (9), 8210-8235.

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