methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate CAS 84088-50-6

methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

纯度 97%+现货药物标准品
CAS 号84088-50-6
分子式C12H11NO4
分子量233.22 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate CAS 84088-50-6 结构式 Chemical Structure

产品介绍 Description

methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate（methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate）是药物分析与质量控制领域常用的药物标准品，CAS 号 84088-50-6。分子式 C12H11NO4，分子量 233.22。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate的分子量为233.22 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C12H11NO4 的methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate（methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate），其CAS登记号是 84088-50-6，分子量为 233.22 g/mol。 methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate（C12H11NO4）含有氨基酸衍生物，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有

应用场景：从实际应用出发，methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate（CAS 84088-50-6）在化学分析中作为关键的基准对照物质。 推荐以methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1

理化性质 Physical & Chemical Properties

中文名称methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
分子式C12H11NO4
分子量233.22 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1981年
含氮原子数1

相关专利 Related Patents

  1. 发明人钱学锋，马晓峰，刘建华. "一种methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 108564840 A, 授权公告日 2021-04-20.
  2. 发明人刘建华，李文辉，赵玉洁. "Method for the Synthesis of methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate" [P]. 中国发明专利, 专利号 CN 108870870 A, 授权公告日 2021-10-28.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2023, 1024, 466-494.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate as an Impurity". Talanta, 2016, 1331, (9), 9611-9638.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate Using HRMS and NMR". Environ. Sci. Technol., 2010, 2149, (10), 8434-8438.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2018, 2255, (10), 9561-9571.

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