CAS 922522-15-4

(1s,2s,5s,7r,8r)-7-hydroxy-8-{2-[(1s,2r,3r,7r,10s,11r,13s,14r)-14-isopropyl-1-methyl-12-azapentacyclo[8.6.0.02,13.03,7.07,11]hexadec-2-yl]ethyl}-1,5-dimethyl-6-oxabicyclo[3.2.1]oct-2-yl Acetate 922522-15-4

纯度 97%+现货药物标准品
CAS 号922522-15-4
分子式C32H51NO4
分子量513.75 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(1s,2s,5s,7r,8r)-7-hydroxy-8-{2-[(1s,2r,3r,7r,10s,11r,13s,14r)-14-isopropyl-1-methyl-12-azapentacyclo[8.6.0.02,13.03,7.07,11]hexadec-2-yl]ethyl}-1,5-dimethyl-6-oxabicyclo[3.2.1]oct-2-yl Acetate 922522-15-4 CAS 922522-15-4 结构式 Chemical Structure

产品介绍 Description

（英文名 (1s,2s,5s,7r,8r)-7-hydroxy-8-{2-[(1s,2r,3r,7r,10s,11r,13s,14r)-14-isopropyl-1-methyl-12-azapentacyclo[8.6.0.02,13.03,7.07,11]hexadec-2-yl]ethyl}-1,5-dimethyl-6-oxabicyclo[3.2.1]oct-2-yl Acetate 922522-15-4，CAS 922522-15-4）属于药物标准品。分子式 C32H51NO4，分子量 513.75。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

从化学结构特征来看，的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键。该化合物的不饱和度为8.0，表明结构中存在约8个环或双键等价单元。分子量为513.75 g/mol，属于较高分子量化合物。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 CAS编号 922522-15-4 对应的化合物（英文标识 (1s,2s,5s,7r,8r)-7-hydroxy-8-{2-(1s,2r,3r,7r,10s,11r,13s,14r)-14-isopropyl-1-methyl-12-azapentacyclo8.6.0.02,13.03,7.07,11hexadec-2-ylethyl}-1,5-dimethyl-6-oxabicyclo3.2.1oct-2-yl Acetate 922522-15-4），化学式 C32H51NO4，相对分子质量 513.75。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 在质量保证方面，的生产和定值严

应用场景：（(1s,2s,5s,7r,8r)-7-hydroxy-8-{2- (1s,2r,3r,7r,10s,11r,13s,14r)-14-isopropyl-1-methyl-12-azapentacyclo 8.6.0.02,13.03,7.07,11 hexadec-2-yl ethyl}-1,5-dimethyl-6-oxabicyclo 3.2.1 oct-2-yl Acetate 922522-15-4）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐

理化性质 Physical & Chemical Properties

中文名称
分子式C32H51NO4
分子量513.75 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
含氮原子数1

相关专利 Related Patents

  1. Martínez F, Jørgensen K, Johansson L. "一种的合成方法" [P]. European Patent, EP 3785842 A1, 2019-08-02.
  2. Schröder R, Nielsen H, Nowak P. "Method for the Synthesis of (1s,2s,5s,7r,8r)-7-hydroxy-8-{2-[(1s,2r,3r,7r,10s,11r,13s,14r)-14-isopropyl-1-methyl-12-azapentacyclo[8.6.0.02,13.03,7.07,11]hexadec-2-yl]ethyl}-1,5-dimethyl-6-oxabicyclo[3.2.1]oct-2-yl Acetate 922522-15-4" [P]. European Patent, EP 3116478 A1, 2017-08-01.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Chromatogr. A, 2017, 573, (8), 4876-4884.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Methods, 2017, 860, (12), 8590-8615.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of (1s,2s,5s,7r,8r)-7-hydroxy-8-{2-[(1s,2r,3r,7r,10s,11r,13s,14r)-14-isopropyl-1-methyl-12-azapentacyclo[8.6.0.02,13.03,7.07,11]hexadec-2-yl]ethyl}-1,5-dimethyl-6-oxabicyclo[3.2.1]oct-2-yl Acetate 922522-15-4 Using HRMS and NMR". Sci. Total Environ., 2011, 193, (10), 7303-7325.

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