CAS 922718-57-8
1,2,3,4-tetrahydro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoquinoline 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoqu 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline 922718-57-8
| CAS 号 | 922718-57-8 |
| 分子式 | C16H24BNO2 |
| 分子量 | 273.18 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
（英文名 1,2,3,4-tetrahydro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoquinoline 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoqu 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline 922718-57-8，CAS 922718-57-8）属于药物标准品。分子式 C16H24BNO2，分子量 273.18。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
（1,2,3,4-tetrahydro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoquinoline 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoqu 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline 922718-57-8），CAS注册编号 922718-57-8，化学分子式为 C16H24BNO2，分子量 273.18 g/mol。 （C16H24BNO2）含有含氮杂环结构，酰胺类，含羟基，含醚键。较高的碳氢比使其脂溶性较好，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17
应用场景：（1,2,3,4-tetrahydro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoquinoline 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoqu 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline 922718-57-8）作为药物标准品，在化学分析分析领域承担着重要的角色。 推
理化性质 Physical & Chemical Properties
| 中文名称 | |
| 分子式 | C16H24BNO2 |
| 分子量 | 273.18 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 5.5 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1987年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人罗永刚，郭海燕，马晓峰. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 116764455 A, 授权公告日 2023-07-24.
- Stevens L M, Brown S R, Fischer A B. "Method for the Synthesis of 1,2,3,4-tetrahydro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoquinoline 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoqu 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline 922718-57-8" [P]. US Patent, US 9348546 B2, 2021-07-20.
- Williams B T, Johnson M A, Lee S K. "A Process for Preparing High-Purity 1,2,3,4-tetrahydro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoquinoline 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoqu 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline 922718-57-8" [P]. US Patent, US 9121693 B2, 2022-12-13.
参考文献 Literature
- Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Chim. Acta, 2013, 482, (5), 7988-7996.
- Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". J. Nat. Prod., 2021, 1724, (11), 7005-7032.
- Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 1,2,3,4-tetrahydro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-isoquinoline 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoqu 2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline 922718-57-8 Using HRMS and NMR". J. Sep. Sci., 2013, 1838, (2), 8702-8726.
- Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2021, 1048, (4), 8253-8272.
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