7-Methyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester CAS 243641-37-4

243641-37-4 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylic acid tert-butyl ester A817247 tert-butyl 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylate

纯度 97%+现货药物标准品
CAS 号243641-37-4
分子式C14H26N2O2
分子量254.37 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

7-Methyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester 243641-37-4 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylic acid tert-butyl ester A817247 tert-butyl 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylate CAS 243641-37-4 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品7-Methyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester（243641-37-4 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylic acid tert-butyl ester A817247 tert-butyl 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylate，CAS 243641-37-4），分子式 C14H26N2O2，分子量 254.37。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，7-Methyl-3,4-dihydro-2H-1,8naphthyridine-1-carboxylic acid tert-butyl ester的分子量为254.37 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 243641-37-4 对应的化合物7-Methyl-3,4-dihydro-2H-1,8naphthyridine-1-carboxylic acid tert-butyl ester（英文标识 243641-37-4 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylic acid tert-butyl ester A817247 tert-butyl 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylate），化学式 C14H26N2O2，相对分子质量 254.37。 从化学结构特征来看，7-Methyl-3,4-dihydro-2H-1,8naphthyridine-1-carbox

应用场景：从实际应用出发，7-Methyl-3,4-dihydro-2H- 1,8 naphthyridine-1-carboxylic acid tert-butyl ester（CAS 243641-37-4）在化学分析中作为关键的基准对照物质。 推荐以7-Methyl-3,4-dihydro-2H- 1,8 naphthyridine-1-carboxylic acid tert-butyl ester配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约

理化性质 Physical & Chemical Properties

中文名称7-Methyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester
分子式C14H26N2O2
分子量254.37 g/mol
外观形态白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）2025年
含氮原子数2

相关专利 Related Patents

  1. O'Brien P Q, Stevens L M, Patel M V. "一种7-Methyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester的合成方法" [P]. US Patent, US 10938955 B2, 2022-10-06.
  2. 发明人冯建国，孙丽萍，赵玉洁. "Method for the Synthesis of 243641-37-4 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylic acid tert-butyl ester A817247 tert-butyl 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylate" [P]. 中国发明专利, 专利号 CN 116230650 A, 授权公告日 2017-07-26.
  3. 发明人陈志强，郑宇鹏，刘建华. "A Process for Preparing High-Purity 243641-37-4 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylic acid tert-butyl ester A817247 tert-butyl 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylate" [P]. 中国发明专利, 专利号 CN 114749325 A, 授权公告日 2024-08-16.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of 7-Methyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester in Pharmaceutical Formulations". Chromatographia, 2015, 1800, (3), 5811-5817.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 7-Methyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester as an Impurity". Food Chem., 2010, 2025, (9), 6932-6952.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 243641-37-4 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylic acid tert-butyl ester A817247 tert-butyl 7-methyl-3,4-dihydro-2H-1,8-naphthyridine-1-carboxylate Using HRMS and NMR". J. Chromatogr. A, 2020, 2392, 8528-8542.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate 7-Methyl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2019, 868, (6), 3711-3725.

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