4-(氯羰基)苯甲酸甲酯 CAS 7377-26-6

4-(Chlorocarbonyl)benzoic acid methyl ester Terephthalic acid monomethyl ester chloride methyl 4-chlorocarbonylbenzoate Methyl 4-(chlorocarbonyl)benzoate 4-(chlorocarbonyl)-benzoic acid methyl ester methyl 4-(carbonochloridoyl)benzoate methyl 4-chlorocarbonyl benzoate methyl 4-(chloroformyl)benzoate Methyl terephthaloyl chloride 7377-26-6

纯度 97%+现货药物标准品
CAS 号7377-26-6
分子式C9H13ClO3
分子量204.65 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-(氯羰基)苯甲酸甲酯 4-(Chlorocarbonyl)benzoic acid methyl ester Terephthalic acid monomethyl ester chloride methyl 4-chlorocarbonylbenzoate Methyl 4-(chlorocarbonyl)benzoate 4-(chlorocarbonyl)-benzoic acid methyl ester methyl 4-(carbonochloridoyl)benzoate methyl 4-chlorocarbonyl benzoate methyl 4-(chloroformyl)benzoate Methyl terephthaloyl chloride 7377-26-6 CAS 7377-26-6 结构式 Chemical Structure

产品介绍 Description

4-(氯羰基)苯甲酸甲酯（4-(Chlorocarbonyl)benzoic acid methyl ester Terephthalic acid monomethyl ester chloride methyl 4-chlorocarbonylbenzoate Methyl 4-(chlorocarbonyl)benzoate 4-(chlorocarbonyl)-benzoic acid methyl ester methyl 4-(carbonochloridoyl)benzoate methyl 4-chlorocarbonyl benzoate methyl 4-(chloroformyl)benzoate Methyl terephthaloyl chloride 7377-26-6，CAS 号 7377-26-6）是 CATO 佳途自主生产的药物标准品，分子式 C9H13ClO3，分子量 204.65。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

化学式为 C9H13ClO3 的4-(氯羰基)苯甲酸甲酯（4-(Chlorocarbonyl)benzoic acid methyl ester Terephthalic acid monomethyl ester chloride methyl 4-chlorocarbonylbenzoate Methyl 4-(chlorocarbonyl)benzoate 4-(chlorocarbonyl)-benzoic acid methyl ester methyl 4-(carbonochloridoyl)benzoate methyl 4-chlorocarbonyl benzoate methyl 4-(chloroformyl)benzoate Methyl terephthaloyl chloride 7377-26-6），其CAS登记号是 7377-26-6，分子量为 204.65 g/mol。 受分子结构中羧酸类，含羟基，含醚键，含氯取代的影响，4-(氯羰基)苯甲酸甲酯表现为白色至类白色结晶性粉末。（具有轻微卤代物特征气味）。其固体形态的物理化学属性——包括204.65

应用场景：针对化学分析用途，4-(氯羰基)苯甲酸甲酯（4-(Chlorocarbonyl)benzoic acid methyl ester Terephthalic acid monomethyl ester chloride methyl 4-chlorocarbonylbenzoate Methyl 4-(chlorocarbonyl)benzoate 4-(chlorocarbonyl)-benzoic acid methyl ester methyl 4-(carbonochloridoyl)benzoate methyl 4-chlorocarbonyl benzoate methyl 4-

理化性质 Physical & Chemical Properties

中文名称4-(氯羰基)苯甲酸甲酯
分子式C9H13ClO3
分子量204.65 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1959年
卤素含量Cl取代

相关专利 Related Patents

  1. Johansson L, Björnsson E, Lefèvre J P. "一种4-(氯羰基)苯甲酸甲酯的合成方法" [P]. European Patent, EP 3811302 A1, 2022-05-06.
  2. 发明人沈红梅，刘建华，陈志强. "Method for the Synthesis of 4-(Chlorocarbonyl)benzoic acid methyl ester Terephthalic acid monomethyl ester chloride methyl 4-chlorocarbonylbenzoate Methyl 4-(chlorocarbonyl)benzoate 4-(chlorocarbonyl)-benzoic acid methyl ester methyl 4-(carbonochloridoyl)benzoate methyl 4-chlorocarbonyl benzoate methyl 4-(chloroformyl)benzoate Methyl terephthaloyl chloride 7377-26-6" [P]. 中国发明专利, 专利号 CN 117184613 A, 授权公告日 2019-03-19.
  3. 发明人刘建华，赵玉洁，徐明华. "A Process for Preparing High-Purity 4-(Chlorocarbonyl)benzoic acid methyl ester Terephthalic acid monomethyl ester chloride methyl 4-chlorocarbonylbenzoate Methyl 4-(chlorocarbonyl)benzoate 4-(chlorocarbonyl)-benzoic acid methyl ester methyl 4-(carbonochloridoyl)benzoate methyl 4-chlorocarbonyl benzoate methyl 4-(chloroformyl)benzoate Methyl terephthaloyl chloride 7377-26-6" [P]. 中国发明专利, 专利号 CN 108946211 A, 授权公告日 2021-10-19.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of 4-(氯羰基)苯甲酸甲酯 in Pharmaceutical Formulations". Biomed. Chromatogr., 2011, 2100, (12), 789-795.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-(氯羰基)苯甲酸甲酯 as an Impurity". Sci. Total Environ., 2014, 1747, (1), 8588-8598.

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