3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester CAS 1251002-77-3
3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester
| CAS 号 | 1251002-77-3 |
| 分子式 | C11H18N4O3 |
| 分子量 | 254.29 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester（3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester，CAS 1251002-77-3），分子式 C11H18N4O3，分子量 254.29。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
在质量保证方面，3-Hydroxymethyl-5,6-Dihydro-8H-1,2,4Triazolo4,3-APyrazine-7-Carboxylic Acid Tert-Butyl Ester的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C11H18N4O3 的3-Hydroxymethyl-5,6-Dihydro-8H-1,2,4Triazolo4,3-APyrazine-7-Carboxylic Acid Tert-Butyl Ester（3-Hydroxymethyl-5,6-Dihydro-8H-1,2,4Triazolo4,3-APyrazine-7-Carboxylic Acid Tert-Butyl Ester），其CAS登记号是 1251002-77-3，分子量为 254.29 g/mol。 3-Hydr
应用场景：从实际应用出发，3-Hydroxymethyl-5,6-Dihydro-8H- 1,2,4 Triazolo 4,3-A Pyrazine-7-Carboxylic Acid Tert-Butyl Ester（CAS 1251002-77-3）在化学分析中作为关键的基准对照物质。 推荐以3-Hydroxymethyl-5,6-Dihydro-8H- 1,2,4 Triazolo 4,3-A Pyrazine-7-Carboxylic Acid Tert-Butyl Ester配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度
理化性质 Physical & Chemical Properties
| 中文名称 | 3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester |
| 分子式 | C11H18N4O3 |
| 分子量 | 254.29 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 5.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1990年 |
| 含氮原子数 | 4 |
相关专利 Related Patents
- 发明人林芳，何建平，黄志刚. "一种3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester的合成方法" [P]. 中国发明专利, 专利号 CN 114000520 B, 授权公告日 2025-03-11.
- Sørensen M, Martínez F, Nowak P. "Method for the Synthesis of 3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester" [P]. European Patent, EP 3083778 A1, 2015-07-04.
- Jørgensen K, Johansson L, Schröder R. "A Process for Preparing High-Purity 3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester" [P]. European Patent, EP 3877485 A1, 2020-12-07.
参考文献 Literature
- Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester in Pharmaceutical Formulations". Environ. Sci. Technol., 2021, 211, 6816-6844.
- Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-Hydroxymethyl-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Carboxylic Acid Tert-Butyl Ester as an Impurity". Sci. Total Environ., 2014, 1221, 3053-3058.
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